Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model.

ABSTRACT: Cystic fibrosis is characterized by dehydration of the airway surface liquid layer with persistent mucus obstruction. Th2 immune responses are often manifested as increased mucous cell density (mucous cell metaplasia) associated with mucus obstruction. IL-33 is a known inducer of Th2 immune responses, but its roles in mucus obstruction and related phenotypes in a cystic fibrosis-like lung disease model (i.e., Scnn1b-Tg-positive [Tg+]) mouse, remain unclear. Accordingly, IL-33 knockout (IL-33^KO) Tg+ mice were examined and compared with IL-33 heterozygous (IL-33^HET) Tg+ mice. As compared with IL-33^HET/Tg+ mice, IL-33^KO/Tg+ mice had complete absence of bronchoalveolar lavage fluid eosinophilia, accompanied with significant reduc

SUBMITTER: Lewis BW 

PROVIDER: S-EPMC7714586 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature