Tau PET and relative cerebral blood flow in dementia with Lewy bodies: A PET study.

ABSTRACT:

Purpose

Alpha-synuclein often co-occurs with Alzheimer's disease (AD) pathology in Dementia with Lewy Bodies (DLB). From a dynamic [¹⁸F]flortaucipir PET scan we derived measures of both tau binding and relative cerebral blood flow (rCBF). We tested whether regional tau binding or rCBF differed between DLB patients and AD patients and controls and examined their association with clinical characteristics of DLB.

Methods

Eighteen patients with probable DLB, 65 AD patients and 50 controls underwent a dynamic 130-minute [¹⁸F]flortaucipir PET scan. DLB patients with positive biomarkers for AD based on cerebrospinal fluid or amyloid PET were considered as DLB with AD pathology (DLB-AD+). Receptor parametric mapping (cerebellar gray matter reference region) was

SUBMITTER: Wolters EE 

PROVIDER: S-EPMC7714680 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature