Plasma high-resolution metabolomics identifies linoleic acid and linked metabolic pathways associated with bone mineral density.

ABSTRACT:

Background & aims

There is a considerable degree of variation in bone mineral density (BMD) within populations. Use of plasma metabolomics may provide insight into established and novel determinants of BMD variance, such as nutrition and gut microbiome composition, to inform future prevention and treatment strategies for loss of BMD. Using high-resolution metabolomics (HRM), we examined low-molecular weight plasma metabolites and nutrition-related metabolic pathways associated with BMD.

Methods

This cross-sectional study included 179 adults (mean age 49.5 ± 10.3 yr, 64% female). Fasting plasma was analyzed using ultra-high-resolution mass spectrometry with liquid chromatography. Whole body and spine BMD were assessed by dual energy X-ray absorptiometry and expressed as BMD (

SUBMITTER: Bellissimo MP 

PROVIDER: S-EPMC7714706 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature