External validation of putative biomarkers in eutopic endometrium of women with endometriosis using NanoString technology.

ABSTRACT:

Purpose

To combine different independent endometrial markers to classify the presence of endometriosis.

Methods

Endometrial biopsies were obtained from 109 women with endometriosis as well as 110 control women. Nine candidate biomarkers independent of cycle phase were selected from the literature and NanoString was performed. We compared differentially expressed genes between groups and generated generalized linear models to find a classifier for the disease.

Results

Generalized linear models correctly detected 68% of women with endometriosis (combining deep infiltrating and ovarian endometriosis). However, we were not able to distinguish between individual types of endometriosis compared to controls. From the 9 tested genes, FOS, MMP7, and MMP11 seem to be important

SUBMITTER: Vallve-Juanico J 

PROVIDER: S-EPMC7714803 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature