Characterizing the endometrial fluid cytokine profile in women with endometriosis.

ABSTRACT:

Purpose

To compare growth factor and cytokine profiles in the endometrial secretions of patients with and without endometriosis to determine whether a particular protein profile is predictive of the disease.

Methods

Patients undergoing laparoscopic gynecologic surgery for benign indications were recruited for this prospective cohort study. Prior to surgery, endometrial fluid was aspirated and multiplex immunoassay was used to quantify 7 cytokines and growth factors. During surgery, each patient was staged according to the ASRM staging system for endometriosis. Cytokines and growth factors were evaluated using the Mann-Whitney and Kruskal-Wallis tests. Combinations of cytokines were evaluated using logistic regression analysis, and ROC curves were generated to evaluate the pr

SUBMITTER: Llarena NC 

PROVIDER: S-EPMC7714820 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature