High-Resolution 3D in vivo Brain Diffusion Tensor Imaging at Ultrahigh Fields: Following Maturation on Juvenile and Adult Mice.

ABSTRACT: Diffusion tensor imaging (DTI) is a well-established technique for mapping brain microstructure and white matter tracts in vivo. High resolution DTI, however, is usually associated with low intrinsic sensitivity and therefore long acquisition times. By increasing sensitivity, high magnetic fields can alleviate these demands, yet high fields are also typically associated with significant susceptibility-induced image distortions. This study explores the potential arising from employing new pulse sequences and emerging hardware at ultrahigh fields, to overcome these limitations. To this end, a 15.2 T MRI instrument equipped with a cryocooled surface transceiver coil was employed, and DTI experiments were compared between SPatiotemporal ENcoding (SPEN), a technique that tolerates well s

SUBMITTER: Yon M 

PROVIDER: S-EPMC7714913 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature