Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer.

ABSTRACT:

Background

It is widely accepted that the oxygen level in tumor tissue is significantly lower than the adjacent normal tissue, thus termed hypoxia. Intratumoral hypoxia represents a major driving force in cancer progression, recurrence, metastasis, and decreased survival. Though multiple gene signatures reflect the complex cellular response to hypoxia have been established in several cancer types such as head and neck, breast, and lung cancers, the hypoxic panorama in colorectal cancer (CRC) remains poorly understood.

Methods

A hypoxic signature constituted by a total of 356 genes, including canonical hypoxia-responsive ADM, ANGPTL4, CA9, and VEGFA, was established based on systemic literature search. A total of 1,730 CRC samples across four independent cohorts were used for

SUBMITTER: Qi L 

PROVIDER: S-EPMC7714992 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature