Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease.

ABSTRACT:

Introduction

It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).

Methods

We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of tau, TDP-43, Aβ, and α-synuclein measured in post-mortem tissue from 92 individuals with intermediate to high AD neuropathology. Receiver-operating characteristic (ROC) curves were analyzed for each subregion in order to discriminate TDP-43-negative and TDP-43-positive patients.

Results

TDP-43 was strongly associated with anterior MTL regions, whereas tau was relatively more ass

SUBMITTER: de Flores R 

PROVIDER: S-EPMC7715004 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature