Association study of CCR6 rs3093024 with Rheumatoid Arthritis in a Pakistani cohort.

ABSTRACT: C-C Chemokine receptor 6 (CCR6), an important protein in inflammatory and immunological responses, has been previously reported to be associated with rheumatoid arthritis (RA). Therefore, in order to replicate these findings, a case-control study was conducted on 500 subjects (including 250 RA patients and 250 healthy controls) of Pakistani origin. The aim of this study was to determine the association of CCR6 rs3093024 variant with RA and identify its role in splicing events using bioinformatics tools. The clinical and demographic characteristics of the patients were collected using a well-designed questionnaire. The genotype frequencies of CCR6 rs3093024 variant were determined using tetra-primer ARMS-PCR (amplification of refractory mutation system-polymerase chain reactio

SUBMITTER: Akhtar M 

PROVIDER: S-EPMC7715036 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature