Upper and lower airway inflammation in severe asthmatics: a guide for a precision biologic treatment.

ABSTRACT:

Background and aims

Severe asthma may require the prescription of one of the biologic drugs currently available, using surrogate markers of airway inflammation (serum IgE levels and allergic sensitization for anti-IgE, or blood eosinophils for anti-IL5/IL5R). Our objective: to assess upper and lower airway inflammation in severe asthmatics divided according to the eligibility criteria for one of the target biologic treatments.

Methods

We selected 91 severe asthmatics, uncontrolled despite high-dose ICS-LABA, and followed for >6 months with optimization of asthma treatment. Patients underwent clinical, functional and biological assessment, including induced sputum and nasal cytology. They were then clustered according to the eligibility criteria for omalizumab or mepolizumab/

SUBMITTER: Latorre M 

PROVIDER: S-EPMC7716065 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature