PET-MRI nanoparticles imaging of blood-brain barrier damage and modulation after stroke reperfusion.

ABSTRACT: In an acute ischaemic stroke, understanding the dynamics of blood-brain barrier injury is of particular importance for the prevention of symptomatic haemorrhagic transformation. However, the available techniques assessing blood-brain barrier permeability are not quantitative and are little used in the context of acute reperfusion therapy. Nanoparticles cross the healthy or impaired blood-brain barrier through combined passive and active processes. Imaging and quantifying their transfer rate could better characterize blood-brain barrier damage and refine the delivery of neuroprotective agents. We previously developed an original endovascular stroke model of acute ischaemic stroke treated by mechanical thrombectomy followed by positron emission tomography-magnetic resonance imaging. Cerebral

SUBMITTER: Debatisse J 

PROVIDER: S-EPMC7716090 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature