Personalized warfarin treatment based on the PITX2 single nucleotide polymorphism rs6843082.

ABSTRACT:

Objective

To explore the effect of PITX2 gene rs6843082 single nucleotide polymorphism on the efficacy and adverse reactions of warfarin in patients with atrial fibrillation and hypertension, and to provide a theoretical basis for individualized warfarin treatment.

Methods

Data on 97 patients with atrial fibrillation and hypertension treated in our hospital were collected from September, 2018 to December, 2019. PCR and SNP genotyping techniques were used to measure the genotype at the rs6843082 locus (pituitary homeobox 2, PITX2) using DNA from the peripheral blood cells of all patients. We compared the efficacy of warfarin and the incidence of adverse reactions in patients of different genotypes.

Results

(1) Among 97 subjects, 58 cases (59.79%), 32 cases (32.99%) and

SUBMITTER: Liu T 

PROVIDER: S-EPMC7716133 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature