Clonal expansion of bone marrow CD8⁺ T cells in acute myeloid leukemia patients at new diagnosis and after chemotherapy.

ABSTRACT: CD8⁺ T cells are crucial adaptive immune effectors and express receptors (T cell receptors, TCRs) that specifically recognize and eradicate tumor cells. The diversity of the TCR repertoire is generated by specialized genetic diversification mechanisms, which lead to an extremely variable TCR repertoire that is capable of recognizing a wide range of antigens. However, the variations in CD8⁺ TCR diversity and their clinical implications in acute myeloid leukemia (AML) patients remain unknown. CD8⁺ T cells were enriched from 10 healthy donors and 31 AML patients at diagnosis and after chemotherapy, and TCRβ deep sequencing was performed to analyze CD8⁺ T cell clonal expansion and TCR repertoire diversity. Diminished TCR repertoire diversity and incr

SUBMITTER: Feng Z 

PROVIDER: S-EPMC7716150 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature