Extracellular Traps Released by Neutrophils from Cats are Detrimental to Toxoplasma gondii Infectivity.

ABSTRACT: Toxoplasma gondii is the causative agent of toxoplasmosis, an infectious disease that affects over 30% of the human world population, causing fatal infections in immunocompromised individuals and neonates. The life cycle of T. gondii is complex, and involves intermediate hosts (birds and mammals) and definitive hosts (felines, including domestic cats). The innate immune repertoire against the parasite involves the production of neutrophil extracellular traps (NET), and neutrophils from several intermediate hosts produce NET induced by T. gondii. However, the mechanisms underlying NET release in response to the parasite have been poorly explored. Therefore, the aims of this study were to investigate whether neutrophils from cats produce NET triggered by T. gondii and to understand the mecha

SUBMITTER: Macedo IS 

PROVIDER: S-EPMC7716220 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature