Proteomic Profiling of the Human Fetal Multipotent Mesenchymal Stromal Cells Secretome.

ABSTRACT: Secretome of multipotent mesenchymal stromal cells (MSCs) is actively used in biomedical applications such as alveolar bone regeneration, treatment of cardiovascular disease, and neurodegenerative disorders. Nevertheless, hMSCs have low proliferative potential and production of the industrial quantity of their secretome might be challenging. Human fetal multipotent mesenchymal stromal cells (FetMSCs) isolated from early human embryo bone marrow are easy to expand and might be a potential source for pharmaceutical substances production based on their secretome. However, the secretome of FetMSCs was not previously analyzed. Here, we describe the secretome of FetMSCs using LC-MALDI shotgun proteomics. We identified 236 proteins. Functional annotation of the identified proteins revealed their

SUBMITTER: Lobov AA 

PROVIDER: S-EPMC7716221 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature