Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH.

ABSTRACT: Telomere length has been correlated with various diseases, including cardiovascular disease and cancer. The use of currently available telomere-length measurement techniques is often restricted by the requirement of a large amount of cells (Southern-based techniques) or the lack of information on individual cells or telomeres (PCR-based methods). Although several methods have been used to measure telomere length in tissues as a whole, the assessment of cell-type-specific telomere length provides valuable information on individual cell types. The development of fluorescence in situ hybridization (FISH) technologies enables the quantification of telomeres in individual chromosomes, but the use of these methods is dependent on the availability of isolated cells, which prevents their use with

SUBMITTER: Sharifi-Sanjani M 

PROVIDER: S-EPMC7716275 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature