High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis.

ABSTRACT:

Background

The presentation of pulmonary tuberculosis (PTB) in young children is often clinically indistinguishable from other common respiratory illnesses, which are frequently infections of viral aetiology. As little is known about the role of viruses in children with PTB, we investigated the prevalence of respiratory viruses in children with suspected PTB at presentation and follow-up.

Methods

In an observational cohort study, children < 13 years were routinely investigated for suspected PTB in Cape Town, South Africa between December 2015 and September 2017 and followed up for 24 weeks. Nasopharyngeal aspirates (NPAs) were tested for respiratory viruses using multiplex PCR at enrolment, week 4 and 8.

Results

Seventy-three children were enrolled [median age 22.0 mo

SUBMITTER: van der Zalm MM 

PROVIDER: S-EPMC7716283 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature