Establishing thresholds for important benefits considering the harms of screening interventions.

ABSTRACT:

Context and objective

Standards for clinical practice guidelines require explicit statements regarding how values and preferences influence recommendations. However, no cancer screening guideline has addressed the key question of what magnitude of benefit people require to undergo screening, given its harms and burdens. This article describes the development of a new method for guideline developers to address this key question in the absence of high-quality evidence from published literature.

Summary of method

The new method was developed and applied in the context of a recent BMJ Rapid Recommendation clinical practice guideline for colorectal cancer (CRC) screening. First, we presented the guideline panel with harms and burdens (derived from a systematic review) associated

SUBMITTER: Helsingen LM 

PROVIDER: S-EPMC7716371 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature