Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses.

ABSTRACT:

Background

The cytokine interleukin-25 (IL-25) is recognized as the most relevant initiator of protective T helper 2 (Th2) responses in intestinal helminth infections. This cytokine induces resistance against several species of intestinal helminths, including the trematode Echinostoma caproni. E. caproni has been extensively used as an experimental model to study the factors determining resistance to intestinal infections. In the study reported here, we assessed the role of IL-25 in the generation of resistance in mice infected with E. caproni.

Methods

The factors that determine the production of IL-25 in mice experimentally infected with E. caproni were determined, as were the consequences of IL-25 production in terms of polarization of the immune response and resistance to

SUBMITTER: Alvarez-Izquierdo M 

PROVIDER: S-EPMC7716497 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature