Peritumoral plasmacytoid dendritic cells predict a poor prognosis for intrahepatic cholangiocarcinoma after curative resection.

ABSTRACT:

Background

Plasmacytoid dendritic cells (pDCs) are present in various primary and metastatic human neoplasms; however, their clinical significance in intrahepatic cholangiocarcinoma is not clear.

Methods

To evaluate pDCs' distributions in and around tumors as well as their potential function and predictive value for prognosis in patients undergoing curative resection, we performed immunohistochemistry to examine the expression of pDC marker BDCA2, and CD3, CD4, CD8 and Foxp3 in intratumoral and peritumoral tissues from 359 patients with intrahepatic cholangiocarcinoma and compared with prognostic and clinicopathologic factors.

Results

Results showed that patients with high numbers of BDCA2⁺ pDCs in peritumoral tissues were more likely to have elevated level

SUBMITTER: Hu ZQ 

PROVIDER: S-EPMC7716503 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature