Microarray expression profile analysis of circular RNAs and their potential regulatory role in bladder carcinoma.

ABSTRACT: Dysregulated circular RNAs (circRNAs) often contribute to the occurrence and development of various tumors; however, the function and mechanism of circRNAs are largely unknown in human bladder cancer (BC). In the present study, dysregulated circRNAs between BC and adjacent non‑neoplastic bladder tissues were analyzed by circRNA microarray. We randomly selected 10 upregulated and five downregulated circRNAs for validation by quantitative real‑time PCR. Bioinformatics analysis was further conducted to investigate the potential function of these differentially expressed circRNAs, with the differential expression of hsa_circRNA_100876, mir‑136‑5p, and mRNA‑chromobox 4 (CBX4) subsequently verified. A total of 512 differentially expressed circRNAs were identified after scanning and normalization

SUBMITTER: Li S 

PROVIDER: S-EPMC7716712 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature