Interactions between Environmental Exposures and the Microbiome: Implications for Fetal Programming.

ABSTRACT: Decades of population-based health outcomes data highlight the importance of understanding how environmental exposures in pregnancy affect maternal and neonatal outcomes. Animal model research and epidemiological studies have revealed that such exposures are able to alter fetal programming through stable changes in the epigenome, including altered DNA methylation patterns and histone modifications in the developing fetus and infant. It is similarly known that while microbes can biotransform environmental chemicals via conjugation and de-conjugation, specific exposures can also alter the community profile and function of the human microbiome. In this review, we consider how alterations to the maternal and or fetal/infant microbiome through environmental exposures could directly and indirect

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC7716732 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature