Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study.

ABSTRACT:

Objectives

To examine whether significant depressive symptoms in postmenopausal women increases the risk of subsequent mild cognitive impairment (MCI) and dementia.

Design

Prospective cohort study.

Setting

Thirty nine of the 40 Women's Health Initiative (WHI) clinical centers that participated in a randomized clinical trial of hormone therapy.

Participants

Six thousand three hundred seventy-six postmenopausal women without cognitive impairment aged 65 to 79 at baseline.

Measurements

Depressive disorders were assessed using an eight-item Burnam algorithm and followed annually for a mean period of 5.4 years. A central adjudication committee classified the presence of MCI and probable dementia based on an extensive neuropsychiatric examination.

Results</

SUBMITTER: Goveas JS 

PROVIDER: S-EPMC7716777 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature