Dataset Information

Selpercatinib: First Approval.

ABSTRACT: Selpercatinib (RETEVMO™) is a receptor tyrosine kinase RET (rearranged during transfection) inhibitor being developed by Loxo Oncology for the treatment of cancers harbouring RET alterations. Based on results from the phase I/II LIBRETTO-001 trial, selpercatinib was recently approved by the US FDA for the treatment of RET fusion-positive non-small-cell lung cancer, RET fusion-positive thyroid cancer and RET-mutant medullary thyroid cancer. This article summarizes the milestones in the development of selpercatinib leading to this first approval.

SUBMITTER: Markham A

PROVIDER: S-EPMC7716849 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Selpercatinib: First Approval.

Markham Anthony A

Drugs 20200701 11

Selpercatinib (RETEVMO™) is a receptor tyrosine kinase RET (rearranged during transfection) inhibitor being developed by Loxo Oncology for the treatment of cancers harbouring RET alterations. Based on results from the phase I/II LIBRETTO-001 trial, selpercatinib was recently approved by the US FDA for the treatment of RET fusion-positive non-small-cell lung cancer, RET fusion-positive thyroid cancer and RET-mutant medullary thyroid cancer. This article summarizes the milestones in the developmen ...[more]

PMID: 32557397

Dataset Information

Selpercatinib: First Approval.

Publications

Selpercatinib: First Approval.

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