The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.

ABSTRACT: Innate lymphoid and adaptive immune cells are known to regulate epithelial responses, including mucous cell metaplasia (MCM), but their roles in mucoinflammatory airway diseases, such as cystic fibrosis, remain unknown. Scnn1b transgenic (Scnn1b-Tg⁺) mice, which recapitulate cystic fibrosis-like mucoinflammatory airway disease, deficient in innate lymphoid (Il2rg knockout mice [Il2rg ^KO]), adaptive immune (Rag1 knockout mice [Rag1 ^KO]), or both systems (Il2rg ^KO/Rag1 ^KO), were employed to investigate their respective contributions in the pathogenesis of mucoinflammatory airway disease. As previously reported, immunocompetent Tg⁺ juveniles exhibited spontaneous neonatal

SUBMITTER: Lewis BW 

PROVIDER: S-EPMC7717108 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature