Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets.

ABSTRACT:

Objectives

Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently unavailable. Since niacin is a vitamin with cytoprotective and anti-inflammatory functions, this study aimed to evaluate the possible functional roles and underlying mechanisms of action of niacin as an anti-COVID-19 and -CRC therapy.

Interventions

We used a series of network pharmacology-based and computational analyses to understand and characterize the binding capacity, biological functions, pharmacological targets and therapeutic mechanisms of niacin in CRC/COVID-19.

Measurements and main results

We revealed the clinical characteristics of CRC patients and COVID-19 patients, including predisposin

SUBMITTER: Li R 

PROVIDER: S-EPMC7717147 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature