Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital.

ABSTRACT:

Background

Patients with COVID-19 may be at increased risk for secondary bacterial infections with MDR pathogens, including carbapenemase-producing Enterobacterales (CPE).

Objectives

We sought to rapidly investigate the clinical characteristics, population structure and mechanisms of resistance of CPE causing secondary infections in patients with COVID-19.

Methods

We retrospectively identified CPE clinical isolates collected from patients testing positive for SARS-CoV-2 between March and April 2020 at our medical centre in New York City. Available isolates underwent nanopore sequencing for rapid genotyping, antibiotic resistance gene detection and phylogenetic analysis.

Results

We identified 31 CPE isolates from 13 patients, including 27 Klebsiella pneumoniae a

SUBMITTER: Gomez-Simmonds A 

PROVIDER: S-EPMC7717307 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature