Interclass GPCR heteromerization affects localization and trafficking.

ABSTRACT: Membrane trafficking processes regulate G protein-coupled receptor (GPCR) activity. Although class A GPCRs are capable of activating G proteins in a monomeric form, they can also potentially assemble into functional GPCR heteromers. Here, we showed that the class A serotonin 5-HT_2A receptors (5-HT_2ARs) affected the localization and trafficking of class C metabotropic glutamate receptor 2 (mGluR2) through a mechanism that required their assembly as heteromers in mammalian cells. In the absence of agonists, 5-HT_2AR was primarily localized within intracellular compartments, and coexpression of 5-HT_2AR with mGluR2 increased the intracellular distribution of the otherwise plasma membrane-localized mGluR2. Agonists for either 5-HT_2AR or mGlu

SUBMITTER: Toneatti R 

PROVIDER: S-EPMC7717648 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature