Site-Specific Amino Acid Distributions Follow a Universal Shape.

ABSTRACT: In many applications of evolutionary inference, a model of protein evolution needs to be fitted to the amino acid variation at individual sites in a multiple sequence alignment. Most existing models fall into one of two extremes: Either they provide a coarse-grained description that lacks biophysical realism (e.g., dN/dS models), or they require a large number of parameters to be fitted (e.g., mutation-selection models). Here, we ask whether a middle ground is possible: Can we obtain a realistic description of site-specific amino acid frequencies while severely restricting the number of free parameters in the model? We show that a distribution with a single free parameter can accurately capture the variation in amino acid frequency at most sites in an alignment, as long as we are willing t

SUBMITTER: Johnson MM 

PROVIDER: S-EPMC7717668 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature