New frontiers on the molecular underpinnings of hypospadias according to severity.

ABSTRACT: Hypospadias, which is characterised by the displacement of the urethral meatus from its typical anatomical location in males, shows various degrees of severity. In this systematic review, we surveyed our current understanding of the genetics of isolated hypospadias in humans according to the severity of the condition. We found that sequencing and genotyping approaches were the preferred methods of study and that single nucleotide polymorphisms were the most common finding associated with hypospadias. Most genes fell into four gene-pathway categories related to androgens, oestrogens, growth factors, or transcription factors. Few hypospadias studies classify their findings by severity. Taken together, we argue that it is advantageous to take into consideration the severity of the condition i

SUBMITTER: Pineyro-Ruiz C 

PROVIDER: S-EPMC7717703 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature