Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution.

ABSTRACT:

Background

Traffic-related air pollution (TRAP) is made up of complex mixtures of particulate matter, gases and volatile compounds. However, the effects of TRAP on the cardiopulmonary system in most animal studies have been tested using acute exposure to singular pollutants. The cardiopulmonary effects and molecular mechanisms in animals that are chronically exposed to unmodified air pollution as a whole have yet to be studied. Additionally, sex-dependent toxicity of TRAP exposure has rarely been evaluated.

Objectives

This study sought to assess the cardiopulmonary effect of chronic exposure to unmodified, real-world TRAP in both female and male rats.

Methods

Four-week-old male and female rats were exposed to TRAP or filtered air for 14 months in a novel facility draw

SUBMITTER: Edwards S 

PROVIDER: S-EPMC7717845 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature