Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC7717908 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cheng Yubo Y Saville Luke L Gollen Babita B Isaac Christopher C Belay Abel A Mehla Jogender J Patel Kush K Thakor Nehal N Mohajerani Majid H MH Zovoilis Athanasios A
eLife 20201116
The functional importance of many non-coding RNAs (ncRNAs) generated by repetitive elements and their connection with pathologic processes remains elusive. B2 RNAs, a class of ncRNAs of the B2 family of SINE repeats, mediate through their processing the transcriptional activation of various genes in response to stress. Here, we show that this response is dysfunctional during amyloid beta toxicity and pathology in the mouse hippocampus due to increased levels of B2 RNA processing, leading to cons ...[more]