Cutibacterium acnes Phylotype I and II Strains Interact Differently With Human Skin Cells.

ABSTRACT: Acne vulgaris is one of the most common skin disorders and affects the pilosebaceous units. Although the exact pathogenesis of acne is still unknown, Cutibacterium acnes (formerly known as Propionibacterium acnes) is considered one of the key contributing factors. In fact, a significant association exists between C. acnes strains belonging to phylotype I and acne. However, there is still heavy debate on the exact role of C. acnes in acne and its behavior in the pilosebaceous unit, and more specifically its interactions with the human skin cells. In this study, key elements of the host-pathogen interaction were studied for a collection of C. acnes strains, belonging to phylotype I and II, including association with HaCaT keratinocytes and SZ95 sebocytes, t

SUBMITTER: Spittaels KJ 

PROVIDER: S-EPMC7717938 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature