Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers.

ABSTRACT: The mammalian retina processes sensory signals through two major pathways: a vertical excitatory pathway, which involves photoreceptors, bipolar cells, and ganglion cells, and a horizontal inhibitory pathway, which involves horizontal cells, and amacrine cells. This concept explains the generation of an excitatory center-inhibitory surround sensory receptive fields-but fails to explain the modulation of the retinal output by stimuli outside the receptive field. Electrical imaging of light-induced signal propagation at high spatial and temporal resolution across and within different retinal layers might reveal mechanisms and circuits involved in the remote modulation of the retinal output. Here we took advantage of a high-density complementary metal oxide semiconductor-based microelectrode

SUBMITTER: Lee MJ 

PROVIDER: S-EPMC7717958 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature