The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration.

ABSTRACT: Regeneration of long-bone segmental defects remains a challenge for orthopedic surgery. Current treatment options often require several revision procedures to maintain acceptable alignment and achieve osseous healing. A novel hollow tubular system utilizing magnesium-strontium (Mg-Sr) alloy with autogenous morselized bone filled inside to repair segmental defects was developed. To improve the corrosion and biocompatible properties, two coatings, Ca-P and Sr-P coatings, were prepared on surface of the implants. Feasibility of applying these coated implants was systematically evaluated in vitro and in vivo, and simultaneously to have a better understanding on the relationship of degradation and bone regeneration on the healing process. According to the in vitro corrosion

SUBMITTER: Zhang N 

PROVIDER: S-EPMC7718143 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature