Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19.

ABSTRACT: The aim of this study was to evaluate the impact of early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis on patients admitted to the San Raffaele Hospital (Milan, Italy) with moderate/severe COVID-19 and availability of at least two nasopharyngeal swabs. The primary outcome was the time to nasopharyngeal swab negativization. A multivariable Cox model was fitted to determine factors associated with nasopharyngeal swab negativization. Of 280 patients included, 59 (21.1%) patients were treated with steroids. Differences observed between steroid users and non-users included the proportion of patients with a baseline PaO₂/FiO₂ ≤ 200 mmHg (45.8% vs 34.4% in steroids and non-steroids users, respectively; p = 0

SUBMITTER: Spagnuolo V 

PROVIDER: S-EPMC7718220 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature