High-throughput preparation of radioprotective polymers via Hantzsch's reaction for in vivo X-ray damage determination.

ABSTRACT: Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch's reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently preven

SUBMITTER: Liu G 

PROVIDER: S-EPMC7718248 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature