Maternal blood glucose level and offspring glucose-insulin homeostasis: what is the role of offspring adiposity?

ABSTRACT:

Aims/hypothesis

The aim of this work was to investigate the association of maternal HbA_1c during mid-pregnancy with biomarkers of glucose-insulin homeostasis during early childhood (4-7 years of age) and to assess whether and how offspring adiposity at birth and at age 4-7 years mediates this relationship among 345 mother-child pairs in the Healthy Start Study.

Methods

The exposure was maternal HbA_1c (mmol/mol) measured at 20-34 gestational weeks and categorised into tertiles. The outcomes were offspring fasting glucose, 1/insulin, HOMA2-IR, and HOMA2-B at age 4-7 years. The mediators were per cent fat mass (%FM) at birth, %FM at age 4-7 years, and the sum of the two as a metric of cumulative adiposity. Mediation analyses were conducted via a counterfac

SUBMITTER: Francis EC 

PROVIDER: S-EPMC7718294 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature