A simple and efficient automated microvolume radiosynthesis of [¹⁸F]Florbetaben.

ABSTRACT:

Background

Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot be economically produced on a conventional synthesizer. Alternative approaches are desired to produce small to moderate batches to reduce cost and the amount of reagents and radioisotope needed to produce PET tracers with high molar activity. In this work we describe the first reported microvolume method for production of [¹⁸F]Florbetaben for use in imaging of Alzheimer's disease.

Procedures

The microscale synthesis of [¹⁸F]Florbetaben was adapted from conventional-scale synthesis methods. Aqueous [¹⁸F]fluoride was azeotropic

SUBMITTER: Lisova K 

PROVIDER: S-EPMC7718361 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature