Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders.

ABSTRACT: Over the past decade, large-scale genetic studies have successfully identified hundreds of genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic insight and clinical translation continue to lag the pace of risk variant identification, hindered by the sheer number of targets and their predominant noncoding localization, as well as pervasive pleiotropy and incomplete penetrance. Successful next steps require identification of "causal" genetic variants and their proximal biological consequences; placing variants within biologically defined functional contexts, reflecting specific molecular pathways, cell types, circuits, and developmental windows; and characterizing the downstream, convergent neurobiological impact of polygenicity within an individual.

SUBMITTER: Hernandez LM 

PROVIDER: S-EPMC7718368 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature