Stromal SNAI2 Is Required for ERBB2 Breast Cancer Progression.

ABSTRACT: SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2⁺/ERBB2⁺ breast cancers in which SNAI2 expression in the stroma but not the epithelium correlates with tumor proliferation. To determine how stromal SNAI2 might influence HER2⁺ tumor behavior, Snai2-deficient mice were crossed with a mouse line carrying the ErbB2/Neu protooncogene to generate HER2⁺/ERBB2⁺ breast cancer. Tumors generated in this model expressed SNAI2 in the stroma but not the epithelium, allowing for the role of stromal SNAI2 to be studied without interference from the epith

SUBMITTER: Blanco-Gomez A 

PROVIDER: S-EPMC7718390 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature