Development of fast multi-slice apparent T₁ mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

ABSTRACT:

Purpose

To develop fast multi-slice apparent T₁ (T_1app ) mapping for accurate cerebral blood flow (CBF) quantification with arterial spin labeling (ASL) MRI.

Methods

Fast multi-slice T_1app was measured using a modified inversion recovery echo planar imaging (EPI) sequence with simultaneous application of ASL tagging radiofrequency (RF) and gradient pulses. The fast multi-slice T_1app measurement was compared with the single-slice T_1app imaging approach, repeated per slice. CBF was assessed in healthy adult Wistar rats (N = 5) and rats with acute stroke 24 hours after a transient middle cerebral artery occlusion (N = 5).

Results

The fast multi-slice T_1app measurement was in good agreement with that of a s

SUBMITTER: Ji Y 

PROVIDER: S-EPMC7718392 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature