The cellular basis of distinct thirst modalities.

ABSTRACT: Fluid intake is an essential innate behaviour that is mainly caused by two distinct types of thirst^1-3. Increased blood osmolality induces osmotic thirst that drives animals to consume pure water. Conversely, the loss of body fluid induces hypovolaemic thirst, in which animals seek both water and minerals (salts) to recover blood volume. Circumventricular organs in the lamina terminalis are critical sites for sensing both types of thirst-inducing stimulus^4-6. However, how different thirst modalities are encoded in the brain remains unknown. Here we employed stimulus-to-cell-type mapping using single-cell RNA sequencing to identify the cellular substrates that underlie distinct types of thirst. These studies revealed diverse types of excitatory and inhibitory neuron in

SUBMITTER: Pool AH 

PROVIDER: S-EPMC7718410 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature