Vitreous metabolomics profiling of proliferative diabetic retinopathy.

ABSTRACT:

Aims/hypothesis

Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabolites identified in prior studies and identified novel dysregulated metabolites that may lead to treatment strategies for PDR.

Methods

We analysed metabolites in vitreous samples from 43 PDR patients and 21 non-diabetic epiretinal membrane control patients from Japan (age 27-80 years) via ultra-high-performance liquid chromatography-mass spectrometry. We then investigated the association of a novel metabolite (creatine) with retinal NV in mouse oxygen-induced r

SUBMITTER: Tomita Y 

PROVIDER: S-EPMC7718434 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature