Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes.

ABSTRACT:

Background

Comprehensive proteomics profiling may offer new insights into the dysregulated metabolic milieu of type 2 diabetes, and in the future, serve as a useful tool for personalized medicine. This calls for a better understanding of circulating protein patterns at the early stage of type 2 diabetes as well as the dynamics of protein patterns during changes in metabolic status.

Methods

To elucidate the systemic alterations in early-stage diabetes and to investigate the effects on the proteome during metabolic improvement, we measured 974 circulating proteins in 52 newly diagnosed, treatment-naïve type 2 diabetes subjects at baseline and after 1 and 3 months of guideline-based diabetes treatment, while comparing their protein profiles to that of 94 subjects without diabet

SUBMITTER: Gummesson A 

PROVIDER: S-EPMC7718461 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature