CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy.

ABSTRACT:

Background

Neuroinflammation has been implicated in the pathogenesis of chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease association with exposure to repetitive head impacts (RHI) received though playing contact sports such as American football. Past work has implicated early and sustained activation of microglia as a potential driver of tau pathology within the frontal cortex in CTE. However, the RHI induced signals required to recruit microglia to areas of damage and pathology are unknown.

Methods

Postmortem brain tissue was obtained from 261 individuals across multiple brain banks. Comparisons were made using cases with CTE, cases with Alzheimer's disease (AD), and cases with no neurodegenerative disease and lacked exposure to RHI (controls)

SUBMITTER: Cherry JD 

PROVIDER: S-EPMC7718711 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature