Identification of a six-gene metabolic signature predicting overall survival for patients with lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related deaths worldwide. Lung adenocarcinoma (LUAD) is one of the main subtypes of lung cancer. Hundreds of metabolic genes are altered consistently in LUAD; however, their prognostic role remains to be explored. This study aimed to establish a molecular signature that can predict the prognosis in patients with LUAD based on metabolic gene expression.

Methods

The transcriptome expression profiles and corresponding clinical information of LUAD were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. The differentially expressed genes (DEGs) between LUAD and paired non-tumor samples were identified by the Wilcoxon rank sum test. Univariate Cox regression analysis and the lasso Cox regression model

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7718790 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature