Expression and phylogeny of multidrug resistance protein 2 and 4 in African white backed vulture (Gyps africanus).

ABSTRACT: Diclofenac toxicity in old world vultures is well described in the literature by both the severity of the toxicity induced and the speed of death. While the mechanism of toxicity remains unknown at present, the necropsy signs of gout suggests primary renal involvement at the level of the uric acid excretory pathways. From information in the chicken and man, uric acid excretion is known to be a complex process that involves a combination of glomerular filtration and active tubular excretion. For the proximal convoluted tubules excretion occurs as a two-step process with the basolateral cell membrane using the organic anion transporters and the apical membrane using the multidrug resistant protein to transport uric acid from the blood into the tubular fluid. With uric acid excretion seemingl

SUBMITTER: Nethathe B 

PROVIDER: S-EPMC7718797 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature