Phospho-islands and the evolution of phosphorylated amino acids in mammals.

ABSTRACT:

Background

Protein phosphorylation is the best studied post-translational modification strongly influencing protein function. Phosphorylated amino acids not only differ in physico-chemical properties from non-phosphorylated counterparts, but also exhibit different evolutionary patterns, tending to mutate to and originate from negatively charged amino acids (NCAs). The distribution of phosphosites along protein sequences is non-uniform, as phosphosites tend to cluster, forming so-called phospho-islands.

Methods

Here, we have developed a hidden Markov model-based procedure for the identification of phospho-islands and studied the properties of the obtained phosphorylation clusters. To check robustness of evolutionary analysis, we consider different models for the reconstructio

SUBMITTER: Moldovan M 

PROVIDER: S-EPMC7718798 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature