Comprehensive pathway-related genes signature for prognosis and recurrence of ovarian cancer.

ABSTRACT:

Background

Ovarian cancer (OC) is a highly malignant disease with a poor prognosis and high recurrence rate. At present, there is no accurate strategy to predict the prognosis and recurrence of OC. The aim of this study was to identify gene-based signatures to predict OC prognosis and recurrence.

Methods

mRNA expression profiles and corresponding clinical information regarding OC were collected from The Cancer Genome Atlas (TCGA) database. Gene set enrichment analysis (GSEA) and LASSO analysis were performed, and Kaplan-Meier curves, time-dependent ROC curves, and nomograms were constructed using R software and GraphPad Prism7.

Results

We first identified several key signalling pathways that affected ovarian tumorigenesis by GSEA. We then established a nine-gene-based

SUBMITTER: Zhao X 

PROVIDER: S-EPMC7718801 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature